The RIC8A antibody from MyBioSource.com is a Mouse Monoclonal antibody to RIC8, RIC8A, and xtric-8. This antibody recognizes Human antigen. The RIC8A antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Mouse monoclonal RIC8A antibody
RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex. RIC8A also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation